广西海洋药物重点实验室

                                                                          

       袁清霞，博士，中共党员，硕士生导师，长期致力于海洋中药多糖及寡糖类药物及产品研发工作。在中药多糖类抗凝新药、免疫增强剂、抗氧化剂、新型益生元等研发方面取得了显著成果。累计发表科研论文40余篇，其中以第一作者或通讯作者在中科院SCI分区大类二区及以上期刊发表论文20余篇，包括在《Carbohydrate Polymers》《Journal of Agricultural and Food Chemistry》《International Journal of Biological Macromolecules》等中科院大类一区Top期刊发表15篇，单篇最高他引次数达300余次；申请国家或国际发明专利15项，其中已获授权9项。担任多个SCI期刊审稿人。在教学指导方面，曾指导本科生荣获广西“挑战杯”科技竞赛特等奖1项，并获得全国“挑战杯”科技竞赛二等奖1项。

联系方式

qingxiayuan@163.com

研究方向

海洋中药糖生物化学及药理学研究

获奖及荣誉

2022年广西中医药大学先进工作者

2022年指导学生获第十七届全国“挑战杯”科技竞赛二等奖

2021年指导学生获广西第十届“挑战杯”科技竞赛特等奖

2016年获南京农业大学优秀博士毕业研究生

2015年获博士研究生国家奖学金

2012年获硕士研究生国家奖学金

教育背景与工作经历

2024.12 -至今           广西中医药大学  海洋药物研究院   研究员

2020.12-2024.11      广西中医药大学  海洋药物研究院   副研究员

2019.05-2020.11      广西中医药大学  海洋药物研究院   讲师

2016.09-2019.05      中南民族大学  药学院   讲师

2013.09-2016.06      南京农业大学  食品科技学院  博士

主持课题

国家自然科学基金（青年），2025/01-2027/12

国家自然科学基金（地区），2022/01-2025/12

广西自然科学基金（面上），2025.03-2028.02

广西自然科学基金（青年），2020.07-2023.07

代表性成果

主要代表性论文(#共同一作；*通讯作者)：

(1) Huang Jinwen, Wang Huiqi, Chen Huaqun, Liu Zidong, Zhang Xuedong, Tang Hao, Wei Shiying, Zhou Wangting, Yang Xinzhou, Liu Yonghong, Zhao Longyan*, Yuan Qingxia*. Structural analysis and in vitro fermentation characteristics of an Avicennia marina fruit RG-I pectin as a potential prebiotic, Carbohydrate Polymers, 2024, 338, 122236. (一区TOP, IF: 11.2)

(2) Yuan Qingxia#, Liang Rongyi#, Lv Kunling, Shi Xiaohuo, Leng Jing, Liu Yonghong, Xiao Jian*, Zhang Lifeng*, Zhao Longyan*, Structural characterization of a Chlorella heteropolysaccharide by analyzing its depolymerized product and finding an inducer of human dendritic cell maturation, Carbohydrate Polymers, 2024, 333, 122000. 

(3) Tang Hao#, Huang Jinwen#, Yuan Qingxia#,*, Lv Kunling, Ma Haiqiong, Li Tingting, Liu Yonghong, Mi Shunli*, Zhao Longyan*, A regular Chlorella mannogalactan and its sulfated derivative as a promising anticoagulant: Structural characterization and anticoagulant activity, Carbohydrate Polymers, 2023, 314, 120956.

(4) Yuan Qingxia, Shi Xiang, Ma Haiqiong, Yao Yue, Zhang Baoshun, Zhao Longyan. Recent progress in marine chondroitin sulfate, dermatan sulfate, and chondroitin sulfate/dermatan sulfate hybrid chains as potential functional foods and therapeutic agents, International Journal of Biological Macromolecules, 2024, 262, 129969. (一区Top, IF: 8.2)

(5) Yuan Qingxia#, Li Hong#, Wang Qian#, Sun Shujing, Fang Ziyu, Tang Hao, Shi Xiaohuo, Wen Jing, Huang Lianghua, Bai Meng, Zhong Shengping, Liu Yonghong*, Gao Chenghai*, Zhao Longyan*, Deaminative-cleaved S. monotuberculatus fucosylated glycosaminoglycan: Structural elucidation and anticoagulant activity. Carbohydrate Polymers, 2022, 298, 120072. 

(6) Yuan Qingxia#, Lv Kunling#, Huang Jinwen, Sun Shujing, Fang Ziyu, Tan Hongjie Li Hong, Chen Dan, Zhao Longyan*, Gao Chenghai*, Liu Yonghong*. Simulated digestion, dynamic changes during fecal fermentation and effects on gut microbiota of Avicennia marina (Forssk.) Vierh. fruit non-starch polysaccharides, Food Chemistry: X, 2022, 16: 100475. (一区TOP, IF: 6.1) 

(7) Chen Guijie, Chen Dan, Zhou Wangting, Peng Yujia, Chen Chunxu, Shen Wenbiao, Zeng Xiaoxiong*, Yuan Qingxia*, Improvement of metabolic syndrome in high-fat diet-induced mice by yeast β-glucan is linked to inhibited proliferation of Lactobacillus and Lactococcus in gut microbiota, Journal of Agricultural and Food Chemistry, 2021, 69, 27, 7581–7592. (一区TOP, IF: 6.1)

(8) Yuan Qingxia, Zhang Xiandong, Ma Mingyang, Long Tao, Xiao Chulei, Zhang Jing, Liu Jikai*, Zhao Longyan*, Immunoenhancing glucuronoxylomannan from Tremella aurantialba Bandoni et Zang and its low-molecular-weight fractions by radical depolymerization: Properties, structures and effects on macrophages, Carbohydrate Polymers, 2020, 238: 116184.

(9) Yuan Qingxia, Zhang Jing, Xiao Chulei, Harqin Chaligan, Ma Mingyang, Long Tao, Li Zhenghui, Yang Yanling, Liu Jikai*, Zhao Longyan*, Structural characterization of a low-molecular-weight polysaccharide from Angelica pubescens Maxim. f. biserrata Shan et Yuan root and evaluation of its antioxidant activity, Carbohydrate Polymers, 2020, 236: 116047.

(10) Li Hong#, Yuan Qingxia#, Lv Kunling#, Ma Haiqiong, Gao Chenghai, Liu Yonghong, Zhang Siyuan*, Zhao Longyan*, Low-molecular-weight fucosylated glycosaminoglycan and its oligosaccharides from sea cucumber as novel anticoagulants: A review, Carbohydrate Polymers, 2020, 117034.

(11) Yuan Qingxia, Li Hong, Wei Ziyi, Lv Kunling, Gao Chenghai, Liu Yonghong, Zhao Longyan*, Isolation, structures and biological activities of polysaccharides from Chlorella: A review, International Journal of Biological Macromolecules, 2020, 163: 2199–2209. 

(12) Yuan Qingxia, Zhao Longyan, Li Zhenghui, Harqin Chaligan, Peng Yunfeng, Liu Jikai*, Physicochemical analysis, structural elucidation and bioactivities of a high-molecular-weight polysaccharide from Phellinus igniarius mycelia, International Journal of Biological Macromolecules, 2018, 120: 1855-1864.

(13) Yuan Qingxia, Zhao Longyan*, The mulberry (Morus alba L.) fruit—A review of characteristic components and health benefits, Journal of Agricultural and Food Chemistry, 2017, 65(48): 10383–10394.（ESI高被引论文）

(14) Yuan Qingxia, Xie Y., Wang W., Yan Y., Ye H., Jabbar S., Zeng X. Extraction optimization, characterization and antioxidant activity in vitro of polysaccharides from mulberry (Morus alba L.) leaves, Carbohydr Polym, 2015, 128: 52–62.

(15) Yuan Qingxia, Zhao L., Cha Q., Sun Y., Ye H., Zeng X. Structural characterization and immunostimulatory activity of a homogeneous polysaccharide from Sinonovacula constricta, J Agric Food Chem, 2015, 63(36): 7986–7994.

(16) Zhang Xuedong, Yan Guanwei, Liu Xinming, Fu Jiwwen, Shi Xiang, Cao Pei, Sun Yuqian, Zhong Shengping, Nong Jiale, Jiang Peiqi, Liu Yonghong, Zhang Baoshun*, Yuan Qingxia*, Zhao Longyan*. Structural characterization and anticoagulant potential of Colochirus quadrangularis fucosylated glycosaminoglycan 5−12 oligomers with unusual branches, Marine Drugs, 2025, 23, 64. (大类二区, IF: 5.4)

(17) Yao, Yue; Tang, Hao; Ma, Haiqiong; Liu, Zidong; Huang, Jinwen; Yang, Xiufen; Zhao, Longyan; Yuan, Qingxia*, Chondroitin sulfate/dermatan sulfate hybrid chains from swim bladder: Isolation, structural analysis, and anticoagulant activity, Marine Drugs, 2024, 22, 9.

(18) Ma Haiqiong, Yuan Qingxia*, Tang Hao, Tan Hongjie, Li Tingting, Wei Shiying, Huang Jinwen, Yao Yue, Hu Yaping, Zhong Shengping, Liu Yonghong, Gao Chenghai, Zhao Longyan, Structural elucidation of a glucan from Trichaster palmiferus by its degraded products and preparation of its sulfated derivative as an anticoagulant. Marine Drugs, 2023, 21, 148.

(19) Lv Kunling#, Yuan Qingxia#, Li Hong, Li Tingting, Ma Haiqiong, Gao Chenghai, Zhang Siyuan*, Liu Yonghong, Zhao Longyan*, Chlorella pyrenoidosa polysaccharides as a prebiotic to modulate gut microbiota: Physicochemical properties and fermentation characteristics in vitro, Foods, 2022, 11(5): 725.

近年申请及授权的主要发明专利：

(1) Yuan Qingxia; Zhao Longyan; Li Hong; Wei Ziyi; Low-molecular-weight Tremella Aurantialba glucuronoxylomannan as well as preparation method and application thereof, 2021-08-10, USA, 17/429,908(美国授权)

(2) Yuan Qingxia; Zhao Longyan; Li Hong; Wei Ziyi; Low-molecular-weight Tremella Aurantialba glucuronoxylomannan as well as preparation method and application thereof, 2021-07-05, Australia, 2021103870(澳大利亚授权)

(3) 袁清霞; 赵龙岩; 李宏; 韦子怡; 一种低分子量金耳葡糖醛酸-木甘聚糖及其制备方法和应用, 2021-04-27, 中国, ZL202010061256.9(授权)

(4) 袁清霞; 赵龙岩; 李宏; 韦子怡; 一种天然低分子量独活多糖及其制备方法和应用，2021-01-20, 中国, ZL202010064940.2(授权)

(5) 袁清霞; 赵龙岩; 马海琼; 唐浩; 谭鸿杰; 李婷婷; 魏时英; 黄金文; 姚玥; 胡亚平; 一种海蛇尾多糖硫酸酯衍生物的制备方法及应用，2023-02-15，中国，ZL202310117014.0. (授权)

(6) 袁清霞; 赵龙岩; 姚玥; 唐浩; 黄金文; 刘梓栋; 一种鱼鳔硫酸软骨素-硫酸皮肤素杂合链及其制备方法与应用, 中国, 202311468537.6.

(7) 赵龙岩; 袁清霞; 唐浩; 黄金文; 吕坤凌; 一种小球藻甘露半乳聚糖或其硫酸酯化合物和应用, 2023-02-07, 中国, ZL202310072292.9(授权)

(8) 赵龙岩; 袁清霞; 李婷婷; 马海琼; 李宏; 唐浩; 黄金文; 魏时英; 钟声平; 米顺利; 徐新亚; 刘永宏; 高程海; 一种具有强效抗凝活性的海带多糖及其制备方法和应用, 2022-04-19, 中国, ZL202210411873.6(授权)

(9) Zhao L., Yuan Q., Tang H., Huang J., Lv K. Chlorella mannogalactan or sulfated chlorella mannogalactan compound and application of sulfated chlorella mannogalactan compound., 2024-04-04, USA, 18/626,334 (申请)

(10) 袁清霞, 赵龙岩, 黄金文, 陈华群, 王慧琦, 刘梓栋, 张雪冬. 一种RG-I型榄钱多糖及其制备方法与应用, 中国, 202410512590.X. (申请)