广西海洋药物重点实验室

       罗小卫，博士，研究员，硕士生导师，海洋药物研究院副院长。广西杰出青年科学基金获得者，入选中央组织部“西部之光”学者、广西中医药大学“岐黄工程”高层次人才团队带头人和“桂派杏林青年英才”，获2023年广西科技奖-自然科学类三等奖（排名第1）。主持（完成）国家自然科学基金项目3项和广西科技项目3项，以第一/通讯作者（含并列）在J Med Chem，Org Chem Front等学术期刊发表论文50篇，主编专著1部，申请或授权发明专利15件，转让专利1件。担任中国菌物学会菌物化学专业委员会委员，广西海洋学会副理事长、广西药学会海洋药物专业委员会常务委员兼秘书，Marine Drugs期刊Guest editor，《中草药》杂志青年编委等。

联系方式

luoxiaowei1991@126.com

研究方向

（1）北部湾海洋中药共附生微生物资源的发掘与评价；

（2）海洋微生物活性天然产物的发现和药物先导物的优化与成药性研究；

教育背景与工作经历

2024.12-至今         广西中医药大学海洋药物研究院  研究员（破格）；

2021.12-2024.11         广西中医药大学海洋药物研究院  副研究员；

2019.06-2021.11         广西中医药大学海洋药物研究院  助理研究员；

2014.09-2019.06         中国科学院南海海洋研究所/中国科学院大学  理学博士；

2010.09-2014.06         南方医科大学  医学/文学双学士；

学术兼职

[1] 中国菌物学会菌物化学专业委员会委员

[2] 广西海洋学会副理事长

[3] 广西药学会海洋药物专业委员会常务委员兼秘书

[4] 广西中药材产业协会海洋中药分会委员

[5] 《中草药》杂志第三届青年编委

[6] Marine Drugs期刊Guest editor

荣誉奖励

[1] 中央组织部“西部之光”学者（2023）

[2] 2023年广西科技奖-自然科学类三等奖（排名第1）

[3] 2023年广西高等教育(本科)自治区级教学成果二等奖

[4] 广西中医药大学“记功”（2022）

[5] 博士研究生国家奖学金（2017和2018）

承担项目课题情况

主持科研项目

[1] 国家自然科学基金-区域创新发展联合基金（广西）项目，U24A20809，2025.01-2028.12，在研（合作单位负责人）；

[2] 国家自然科学基金-青年科学基金项目，22007019，2021.01-2023.12，结题；

[3] 国家自然科学基金-地区科学基金项目，82260692， 2023.01-2026.12，在研；

[4] 广西杰出青年科学基金项目，2023JJG140008，2024.01-2027.12，在研；

[5] 广西青年科学基金项目，2020GXNSFBA159001，2020.07-2023.07，结题；

[6] 广西科技基地和人才专项，桂科AD20297003，2021.01-2023.07，结题；

[7] 广西高校中青年教师科研基础能力提升项目，2020KY07032，2020.04-2023.03，结题；

[8] 广西中医药大学 “岐黄工程”高层次人才团队培育项目，202407，2024.01-2026.12，在研；

[9] 广西中医药大学 “桂派杏林青年英才”，2022C038，2022.01-2024.12，结题； 

主要参与项目

[1] 国家自然科学基金-区域创新发展联合基金（广西）项目，U20A20101，2021.01-2024.12，结题；

[2] 国家自然科学基金-地区科学基金项目，82160669，2022.01-2025.12，在研；

[3] 广西第五批 “八桂学者”专项，2019.03-2024.02，结题；

[4] 广西自然科学基金-创新研究团队项目，2020GXNSFGA297002，2021.01-2024.12，结题；

[5] 广西自然科学基金-粤桂联合基金（重点项目），2021GXNSFDA075010，2021.04-2025.03，结题；

代表性学术论文

以第一(#)或通讯(*)作者发表SCI等学术论文50篇，代表性论文如下：

[35] Chen Chunmei#; Xiao Lingxiang#; Luo Xiaowei#; Cai Jian; Huang Lishan; Tao Huaming; Zhou Xuefeng*; Tan Yanhui*; Liu Yonghong*, Identifying marine-derived tanzawaic acid derivatives as novel inhibitors against osteoclastogenesis and osteoporosis via downregulation of NF-κB and NFATc1 activation. Journal of Medicinal Chemistry, 2024, 67(4): 2602–2618. (IF=7.3, 1区top)

[34] Gan Xia#; Luo Xiaowei#; Chen Jingqin; Fang Wenxuan; Nie Mingyi; Lu Humu; Liu Yongyong*; Wang Xueni*, Ilicicolin C suppresses the progression of prostate cancer by inhibiting PI3K/AKT/mTOR pathway. Molecular and Cellular Biochemistry, 2024, doi: 10.1007/s11010-024-05026-9.(IF=3.5, 2区)

[33] Wang Jiaxi#; Lu Humu#; Fang Wenxuan; Lin Miaoping; Feng Yuyao; Qi Xin; Gao Chenghai; Liu Yonghong; Wang Xueni*; Luo Xiaowei*, Antiproliferative effects of resorcylic acid lactones from the Beibu Gulf coral-derived fungus Curvularia lunata GXIMD 02512 on prostate cancer cells, RSC Advances, 2024,14, 38697–38705. (IF=3.9, 3区)

[32] Lin Miaoping #; Tan Yanhui #; Lu Humu; Feng Yuyao; Li Min; Gao Chenghai; Liu Yonghong *; Luo Xiaowei *, Azaphilone derivatives with RANKL-induced osteoclastogenesis inhibition from the mangrove endophytic fungus Diaporthe sp. Chinese Journal of Natural Medicines, 2024, doi: 10.1016/S1875-5364(24)60730-2. (IF=4.0, 2区/卓越期刊)

[31] Cai Jian#; Li Min#; Chen Chunmei#; Yang Bin; Gao Chenghai; Liu Yonghong; Luo Xiaowei*; Tan Yanhui*; Zhou Xuefeng*, Peniditerpenoids A and B: oxidized indole diterpenoids with osteoclast differentiation inhibitory activity from a mangrove-sediment-derived Penicillium sp. Journal of Natural Products, 2024, 87(5): 1401–1406. (IF=3.3, 2区top)

[30] Qin Yuning#; Lu Humu#; Qi Xin; Lin Miaoping; Gao Chenghai; Liu Yonghong*; Luo Xiaowei*, Recent advances in chemistry and bioactivities of secondary metabolites from the genus Acremonium. Journal of Fungi, 2024, 10(1): 37. (IF=4.7, 2区)

[29] Li Xinlong; Cai Jian*; Chen Xinqi; Wu Yanghongyu; Liu Yonghong; Luo Xiaowei *; Zhou Xuefeng*, Discovery and bioactivity evaluation of citrinin derivatives from the mangrove sediment-derived fungus Talaromyces sp. SCSIO 41428, Chemistry & Biodiversity, 2024, e202401938. (IF=2.3, 3区)

[28] Fu Jun#; Luo Xiaowei#; Lin Miaoping; Xiao Zimin; Huang Lishan; Wang Jiaxi; Zhu Yongyan; Liu Yonghong; Tao Huaming*, Marine-fungi-derived gliotoxin promotes autophagy to suppress Mycobacteria tuberculosis infection in macrophage. Marine Drugs, 2023, 21(12): 616. (IF=6.085, 2区)

[27] Zhang Yanting#; Lin Miaoping#; Qin Yuning; Lu Humu; Xu Xinya; Gao Chenghai; Liu Yonghong*; Luo Wenfang*; Luo Xiaowei*, Anti-Vibrio potential of natural products from marine microorganisms. European Journal of Medicinal Chemistry, 2023, 252: 115330. (IF=7.088, 1区top)

[26] Wang Jiamin#, Qin Yuning#, Lin Miaoping, Song Yingying, Lu Humu, Xu Xinya, Liu Yonghong, Zhou Xuefeng*, Gao Chenghai *, Luo Xiaowei*, Marine natural products from the Beibu Gulf: sources, chemistry, and bioactivities. Marine Drugs, 2023, 21(2): 63. (IF=6.085, 2区)

[25] Lin Miaoping#; Tang Zhenzhou#; Wang Jiaxi; Lu Humu; Wang Chenwei; Zhang Yanting; Liu Xinming; Gao Chenghai, Liu Yonghong, Luo Xiaowei*, An epipolythiodioxopiperazine alkaloid and diversified aromatic polyketides with cytotoxicity from the Beibu Gulf coral-derived fungus Emericella nidulans GXIMD 02509, Journal of Zhejiang University SCIENCE B, 2023, 24(3): 275–280. (IF=5.552, 2区)

[24] Ye Yuxiu; Liang Jiaqi; She Jianglian; Lin Xiuping; Wang Junfeng; Liu Yonghong; Yang Dehua; Tan Yanhui*; Luo Xiaowei*; Zhou Xuefeng*, Two new alkaloids and a new butenolide derivative from the Beibu Gulf sponge-derived fungus Penicillium sp. SCSIO 41413. Marine Drugs, 2023, 21(1): 27. (IF=6.085, 2区)

[23] Huang Bingyao#; Peng Shuai #; Liu Shifang; Zhang Yanting; Wei Yuxiao; Xu Xinya; Gao Chenghai; Liu Yonghong*; Luo Xiaowei*. Isolation, screening, and active metabolites identification of anti-Vibrio fungal strains derived from the Beibu Gulf coral, Frontiers in Microbiology, 2022, 13: 930981. (IF=6.064, 2区top)

[22] Wang Jiamin#; Li Zhichao#; Zhang Yanting; Chen Chunmei; Chen Weihao; Gao Chenghai; Liu Yonghong; Tan Yanhui; Luo Xiaowei*. A new α-cyclopiazonic acid alkaloid identified from the Weizhou Island coral-derived fungus Aspergillus flavus GXIMD 02503. Journal of Ocean University of China, 2022, 21(5): 1307–1312. (2区/T1级)

[21] Wang Xueni#; Luo Xiaowei#; Gan Xia; Chen Chunmei; Yang Zaizhun; Wen Jing; Fang Wenxuan; Huang Hailing; Gao Chenghai; Zhou Xuefeng; Feng Xiaotao; Liu Yonghong*, Analysis of regulating activities of 5′-epiequisetin on proliferation, apoptosis, and migration of prostate cancer cells in vitro and in vivo. Frontiers in Pharmacology, 2022, 13: 920554. (IF=5.988, 2区top)

[20] Wang Jiamin; Pang, Xiaoyan; Chen Chunmei; Gao Chenghai; Zhou Xuefeng; Liu Yonghong*; Luo Xiaowei*. Chemistry, biosynthesis, and biological activity of halogenated compounds produced by marine microorganisms, Chinese Journal of Chemistry, 2022, 40(14): 1729–1750. (Front Cover article, IF=5.56, 2区/卓越期刊)

[19] Lu Humu#; Tan Yanhui#; Zhang Yanting; Li Zhichao; Chen Jinying; Gao Chenghai; Liu Yonghong*; Luo Xiaowei*. Osteoclastogenesis inhibitory phenolic derivatives produced by the Beibu Gulf coral-associated fungus Acremonium sclerotigenum GXIMD 02501. Fitoterapia, 2022, 159: 105201.

[18] Chen Chunmei#; Ren Xue#; Tao Huaming; Cai Wenteng; Chen Yuchi; Luo Xiaowei*; Guo Peng*; Liu Yonghong*. Anti-inflammatory polyketides from an alga-derived fungus Aspergillus ochraceopetaliformis SCSIO 41020. Marine Drugs, 2022, 20(5): 295. (IF=6.085, 2区)

[17] Zhang Yanting#; Li Zhichao#; Huang Bingyao; Liu Kai; Peng Shuai; Liu Xinming; Gao Chenghai; Liu Yonghong*; Tan Yanhui*; Luo Xiaowei*. Anti-osteoclastogenic and antibacterial effects of chlorinated polyketides from the Beibu Gulf coral-derived fungus Aspergillus unguis GXIMD 02505. Marine Drugs, 2022, 20(3): 178. (IF=6.085, 2区)

[16] Luo Xiaowei *,#; Cai Guodi#; Guo Yinfeng#; Gao Chenghai; Huang Weifeng; Zhang Zhenhua; Lu Humu; Liu Kai; Chen Jianghe; Xiong Xiaofeng; Lei Jinping; Zhou Xuefeng*; Wang Junjian *; Liu Yonghong*. Exploring the marine-derived ascochlorins as novel human dihydroorotate dehydrogenase inhibitors for treatment of triple-negative breast cancer. Journal of Medicinal Chemistry, 2021, 64(18): 13918–13932. (Supplementary Cover, IF=7.446, 1区top)

[15] Guo Lang#; Luo Xiaowei#; Yang Ping#; Zhang Yanting; Huang Jialuo; Wang Hong; Guo Yinfeng; Huang Weifeng; Chen Zhiqiang; Wang Shusheng; Wang Junjian; Lei Jinping*; Xiang Songtao*; Liu Yonghong*. Ilicicolin A exerts antitumor effect in castration-resistant prostate cancer via suppressing EZH2 signaling pathway. Frontiers in Pharmacology, 2021, 12: 723729. (IF=5.81, 2区)

[14] Chen Chunmei; Chen Weihao; Tao Huaming; Yang Bin; Zhou Xuefeng; Luo Xiaowei*; Liu Yonghong*. Diversified polyketides and nitrogenous compounds from the mangrove endophytic fungus Penicillium steckii SCSIO 41025. Chinese Journal of Chemistry, 2021, 39: 2132–2140. (IF=6.0, 2区/卓越期刊)

[13] Chen Chunmei; Chen Weihao; Pang Xiaoyan; Liao Shengrong; Wang Junfeng; Lin Xiuping; Yang Bin; Zhou Xuefeng; Luo Xiaowei*; Liu Yonghong*. Pyrrolyl 4-quinolone alkaloids from the mangrove endophytic fungus Penicillium steckii SCSIO 41025: Chiral resolution, configurational assignment, and enzyme inhibitory activities. Phytochemistry, 2021, 186: 112730. (IF=4.072, 2区)

[12] Li Kunlong; Su Ziqi; Gao Yongli; Lin Xiuping; Pang Xiaoyan; Yang Bin; Tao Huaming; Luo Xiaowei*; Liu Yonghong*; Zhou Xuefeng*, Cytotoxic minor piericidin derivatives from the actinomycete strain Streptomyces psammoticus SCSIO NS126. Marine Drugs, 2021, 19(8): 428. (IF=5.118, 2区)

[11] Zhang Zhenhua#; Zhang Yidi#; Yang Chunju#; Wang Qianyu; Wang Hong; Zhang Yanting; Deng Wenbin; Nie Yichu; Liu Yonghong; Luo Xiaowei*; Huang Jie*; Wang Junjian*. Antitumor effects of 3-bromoascochlorin on small cell lung cancer via inhibiting MAPK pathway. Cell Biology International, 2021, 45(11): 2380-2390.

[10] Luo Xiaowei*#; Chen Chunmei; Li Kunlong; Lin Xiuping; Gao Chenghai; Zhou Xuefeng; Liu Yonghong*. Sesquiterpenoids and meroterpenoids from a mangrove derived fungus Diaporthe sp. SCSIO 41011. Natural Product Research, 2021, 35(2): 282–288.

[9] Luo Xiaowei; Gao Chenghai; Lu Humu; Wang Jiamin; Su Ziqi; Tao Huaming; Zhou Xuefeng; Yang Bin*; Liu Yonghong*. HPLC-DAD-guided isolation of diversified chaetoglobosins from the coral-associated fungus Chaetomium globosum C2F17. Molecules, 2020, 25(5): 1237.

[8] Chen Chunmei; Tao Huaming; Chen Weihao; Yang Bin; Zhou Xuefeng; Luo Xiaowei*; Liu Yonghong*. Recent advances in the chemistry and biology of azaphilones. RSC Advances, 2020, 10(17): 10197−10220.

[7] Luo Xiaowei; Chen Chunmei; Tao Huaming; Lin Xiuping; Yang Bin; Zhou Xuefeng*; Liu Yonghong*. Structurally diverse diketopiperazine alkaloids from the marine-derived fungus Aspergillus versicolor SCSIO 41016. Organic Chemistry Frontiers, 2019, 6(6): 736–740.(IF=5.455,1区top)

[6] Limbadri Salendra#; Luo Xiaowei#; Lin Xiuping; Wang Junfeng; Yang Bin; Zhou Xuefeng; Liu Yonghong*. Versispiroketal A; an unusual tetracyclic bridged spiroketal from the sponge-associated fungus Aspergillus versicolor SCSIO 41013. Organic & Biomolecular Chemistry, 2019, 17(8): 2182–2186.

[5] Luo Xiaowei; Lin Yun; Lu Yongjun; Zhou Xuefeng*; Liu Yonghong*. Peptides and polyketides from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008. Chinese Journal of Natural Medicines, 2019, 17(2): 149–154.

[4] Luo Xiaowei; Gao Chenghai; Han Fanghai; Chen Xianqiang; Lin Xiuping; Zhou Xuefeng; Wang Junjian*; Liu Yonghong*. A new naphthopyranone from the sponge-associated fungus Penicillium sp. XWS02F62. Magnetic Resonance in Chemistry, 2019, 57(11): 982−986.

[3] Luo Xiaowei; Lin Xiuping; Tao Huaming; Wang Junfeng; Li Jiayi; Yang Bin; Zhou Xuefeng *; Liu Yonghong*. Isochromophilones A–F, cytotoxic chloroazaphilones from the marine mangrove endophytic fungus Diaporthe sp. SCSIO 41011. Journal of Natural Products, 2018, 81(4): 934–941.

[2] Luo Xiaowei#; Yang Jie#; Chen Feimin; Lin Xiuping; Chen Chunmei; Zhou Xuefeng*; Liu Shuwen*; Liu Yonghong*. Structurally diverse polyketides from the mangrove-derived fungus Diaporthe sp. SCSIO 41011 with their anti-influenza A virus activities. Frontiers in Chemistry, 2018, 6: 282.

[1] Luo Xiaowei; Lin Xiuping; Limbadri Salendra; Pang Xiaoyan; Dai Yu; Yang Bin; Liu Juan; Wang Junfeng; Zhou Xuefeng*; Liu Yonghong*. Isobenzofuranones and isochromenones from the deep-sea derived fungus Leptosphaeria sp. SCSIO 41005. Marine Drugs, 2017, 15(7): 204.

申请或授权国内发明专利

[1] 罗小卫; 刘永宏; 王军舰; 高程海; 蔡国弟; 一种壳二孢氯素类化合物及其在制备抗肿瘤药物或二氢乳清酸脱氢酶抑制剂药物中的应用; 2021-02-05; ZL202010844200.0；

[2] 罗小卫; 刘永宏; 王军舰; 高程海; 卢护木. 混源萜类化合物及其制备方法和在制备抗乳腺癌或二氢乳清酸脱氢酶抑制剂药物中的应用; 2022-09-02; ZL202010843144.9；

[3] 罗小卫; 谭艳辉; 林妙萍; 刘永宏; 高程海; 卢护木; 氯代间苯二酚醛类化合物及其在制备破骨细胞分化抑制剂中的应用; 2023-08-15; ZL202210093211.9；

[4] 罗小卫; 谭艳辉; 林妙萍; 刘永宏; 高程海; 覃育宁; 苯乙酸类化合物在制备破骨细胞分化抑制剂中的应用; 2024-12-06; ZL202211484881.X；

[5] 罗小卫; 林妙萍; 谭艳辉; 张艳婷; 高程海; 刘永宏; 溴代嗜氮酮类化合物在制备破骨细胞分化抑制剂上的应用; 2022-11-22; 202211466119.9；

[6] 罗小卫; 王佳敏; 谭艳辉; 林妙萍; 卢护木; 高程海; 刘永宏; 吲哚二萜生物碱类化合物及其制备方法和应用; 2023-11-04; 202311457891.9；