袁清霞，博士，中共党员，硕士生导师，主要从事海洋中药多糖及寡糖类药物及产品研发。主持或参与国家自然科学基金、广西自然科学基金等项目10余项，发表科研论文40余篇，其中以第一作者或通讯作者在J Agr Food Chem，Carbohydr Polym，Food Chem: X等中科院大类一区TOP期刊发表高水平论文10余篇，申请国家或国际发明专利10余项，其中授权8项。担任多个SCI期刊审稿专家。

研究方向：海洋中药糖生物化学及药理学研究

E-mail: qingxiayuan@163.com

招生专业：中药学、海洋中药学

获奖及荣誉：

2022年指导学生获第十七届全国“挑战杯”科技竞赛二等奖

2021年指导学生获广西第十届“挑战杯”科技竞赛特等奖

2016年获南京农业大学优秀博士毕业研究生

2015年获博士研究生国家奖学金

2012年获硕士研究生国家奖学金

教育背景与工作经历：

2019.05-至今 广西中医药大学，海洋药物研究院，副研究员

2016.09-2019.05 中南民族大学，药学院，师资博后（讲师）

2013.09-2016.06 南京农业大学，食品科技学院，博士

主持或参与课题：

1. 国家自然科学基金地区基金, 82160738, 2022/01-2025/12, 主持

2. 广西自然科学基金, 2020GXNSFBA159022, 2020/07-2023/07, 主持

3. 2019年引进博士科研启动基金，2019BS023, 2020/01-2022/12, 主持

4. 广西中医药大学海洋药物研究院启动基金, 2018ZD005-A15, 2018/10-2021/09,主持

5. 广西自然科学基金(杰出青年科学基金), 2020GXNSFFA297005, 2021/01-2024/12, 参与

6. 广西自然科学基金(面上), 2018GXNSFAA050155, 2019/03-2022/02, 参与

7. 广西自然科学基金(人才专项), AD21159002, 2021/08-2023/08, 参与

8. 广西中医药大学第二批“岐黄工程”高层次人才团队培育项目, 2021004, 2021/01-2023/12, 参与

9. 国家自然科学基金青年基金, 31501521, 2016/01-2018/12, 参与

10. 国家自然科学基金青年基金, 31501488, 2016/01-2018/12, 参与

主要代表性成果：

论文(#共同一作)：

[1] Tang H#, Huang J#, Yuan Q#,*, Lv K, Ma H, Li T, Liu Y, Mi S*, Zhao L*. A regular Chlorella mannogalactan and its sulfated derivative as a promising anticoagulant: Structural characterization and anticoagulant activity. Carbohydr Polym, 2023, 314, 120956.(一区TOP，IF 10.723) 

[2] Yuan Q, Li H, Wang Q, Sun S, Fang Z, Tang H, Shi X, Wen J, Huang L, Bai M, Zhong S, Liu Y, Gao C, Zhao L. Deaminative-cleaved S. monotuberculatus fucosylated glycosaminoglycan: Structural elucidation and anticoagulant activity. Carbohydr Polym, 2022, 298, 120072.

[3] Li H#, Yuan Q#, Lv K, Ma H, Gao C, Liu Y, Zhang S, Zhao L. Low-molecular-weight fucosylated glycosaminoglycan and its oligosaccharides from sea cucumber as novel anticoagulants: A review, Carbohydr Polym, 2021, 251: 117034.

[4] Yuan Q, Zhang X, Ma M, Long T, Xiao C, Zhang J, Liu J, Zhao L. Immunoenhancing glucuronoxylomannan from Tremella aurantialba Bandoni et Zang and its low-molecular-weight fractions by radical depolymerization: Properties, structures and effects on macrophages, Carbohydr Polym, 2020, 238: 116184.

[5] Yuan Q, Zhang J, Xiao C, Harqin C, Ma M, Long T, Li Z, Yang Y, Liu J, Zhao L. Structural characterization of a low-molecular-weight polysaccharide from Angelica pubescens Maxim. f. biserrata Shan et Yuan root and evaluation of its antioxidant activity, Carbohydr Polym, 2020, 236: 116047.

[6] Yuan Q, Xie Y, Wang W, Yan Y, Ye H, Jabbar S, Zeng X. Extraction optimization, characterization and antioxidant activity in vitro of polysaccharides from mulberry (Morus alba L.) leaves, Carbohydr Polym, 2015, 128: 52–62.

[7] Chen G, Chen D, Zhou W, Peng Y, Chen C, Shen W, Zeng X*, Yuan Qingxia*. Improvement of metabolic syndrome in high-fat diet-induced mice by yeast β-glucan is linked to inhibited proliferation of Lactobacillus and Lactococcus in gut microbiota, J Agric Food Chem, 2021, 69, 27, 7581–7592. (一区TOP, IF 5.895)

[8] Yuan Q, Zhao L. The mulberry (Morus alba L.) fruit–A review of characteristic components and health benefits, J Agric Food Chem, 2017, 65(48): 10383–10394.

[9] Yuan Q, Zhao L, Cha Q, Sun Y, Ye H, Zeng X. Structural characterization and immunostimulatory activity of a homogeneous polysaccharide from Sinonovacula constricta, J Agric Food Chem, 2015, 63(36): 7986–7994.

[10] Yuan Q, Lv K, Huang J, Sun S, Fang Z, Tan H, Li H, Chen D, Zhao L, Gao C, Liu Y. Simulated digestion, dynamic changes during fecal fermentation and effects on gut microbiota of Avicennia marina (Forssk.) Vierh. fruit non-starch polysaccharides. Food Chem: X, 2022, 16: 100475. (一区TOP, IF 6.443)

[11] Yuan Q, Li H, Wei Z, Lv K, Gao C, Liu Y, Zhao L. Isolation, structures and biological activities of polysaccharides from Chlorella: A review. Int J Biol Macromol, 2020, 163: 2199–2209.(一区TOP, IF 8.025)

[12] Yuan Q, Zhao L, Li Z, Harqin C, Peng Y, Liu J. Physicochemical analysis, structural elucidation and bioactivities of a high-molecular-weight polysaccharide from Phellinus igniarius mycelia, Int J Biol Macromol, 2018, 120: 1855–1864.

[13] Ma H, Yuan Q*, Tang H, Tan H, Li T, Wei S, Huang J, Yao Y, Hu Y, Zhong S, Liu Y, Gao C*, Zhao L*. Structural elucidation of a glucan from Trichaster palmiferus by its degraded products and preparation of its sulfated derivative as an anticoagulant. Mar Drugs, 2023, 21(3): 148. (二区，IF 6.085)

[14] Lv K#, Yuan Q#, Li H, Li T, Ma H, Gao C, Zhang S*, Liu Y, Zhao L*, Chlorella pyrenoidosa polysaccharides as a prebiotic to modulate gut microbiota: Physicochemical properties and fermentation characteristics in vitro, Foods, 2022, 11(5): 725. (二区，IF 5.561)

[15] Qin Y#, Yuan Q#, Zhang Y, Li J, Zhu X, Zhao L, Wen J, Liu J, Zhao L, Zhao J. Enzyme-assisted extraction optimization, characterization and antioxidant activity of polysaccharides from sea cucumber Phyllophorus proteus, Molecules, 2018, 23(3): 590. (二区TOP，IF 4.927)

[16] 袁清霞, 吴凡, 邱丽淳, 叶红, 王晓晴, 曾晓雄*. 鼎湖鳞伞菌胞外多糖PDEPS-1在体外三种模拟消化液中的消化作用. 食品科学, 2016, 37(5): 1-6.(EI收录)

[17] 袁清霞, 朱苗, 李恒, 李莉梅, 曾富华. 仙人掌多糖微胶囊化研究. 食品工业科技2014, 37(05): 202-206.(中文核心)

[18] 袁清霞，赵龙岩，李子娇，程杰，曾富华*，酸法提取仙人掌多糖工艺，食品研究与开发, 2012, 33(3):42-50.(中文核心).

[19] 袁清霞，赵龙岩，程杰，曾富华*，仙人掌多糖药理作用、提取纯化及剂型研究进展，食品与药品, 2012, 14(1):56-59.(中文核心).

[20] 袁清霞，赵龙岩，程杰，曾富华, W/O/W复乳溶剂蒸发法制备水溶性药物微球研究进展, 中国生化药物杂志, 2012, 33(006):920-923.(中文核心).

[21] Chen G, Yuan Q, Saeeduddin M, Ou S, Zeng X, Ye H. Recent advances in tea polysaccharides: Extraction, purification, physicochemical characterization and bioactivities. Carbohydr Polym, 2016, 153: 663–678.

[22] Ye Z, Wang W, Yuan Q, Ye H, Sun Y, Zhang H, Zeng X. Box–Behnken design for extraction optimization, characterization and in vitro antioxidant activity of Cicer arietinum L. hull polysaccharides. Carbohydr Polym, 2016, 147: 354–364.

[23] Dai Z, Lyu W, Xie M, Yuan Q, Ye H, Hu B, Zhou L, Zeng X, Effects of α-galactooligosaccharides from chickpeas on high-fat-diet-induced metabolic syndrome in mice, J Agric Food Chem, 2017, 65 (15): 3160–3166.

[24] Wang W, Li Z, Feng T, Li J, Sun H, Huang R, Yuan Q, Ai H, Liu J. Curtachalasins A and B, Two cytochalasans with a tetracyclic skeleton from the endophytic fungus Xylaria curta E10, Org lett, 2018, 20(24): 7758–7761. (一区TOP，IF 6.072)

[25] Li J, Wang W, Chen H, Li Z, He J, Zheng Y, Sun H, Huang R, Yuan Q, Wang X, Feng T, Liu J. (±)-Xylaridines A and B, highly conjugated alkaloids from the fungus Xylaria longipes, Org lett, 2019, 21(5) 1511–1514.

[26] Guan R, Peng Y, Zhou L, Zheng W, Liu X, Wang P, Yuan Q, Gao N, Zhao L, Zhao J. Precise structure and anticoagulant activity of fucosylated glycosaminoglycan from Apostichopus japonicus: Analysis of its depolymerized fragments. Mar Drugs, 2019, 17, 195.

发明专利：

[1] 袁清霞, 赵龙岩, 李宏, 韦子怡. 一种低分子量金耳葡糖醛酸-木甘聚糖及其制备方法和应用, ZL202010061256.9(授权2021-04-27)

[2] 袁清霞, 赵龙岩, 李宏, 韦子怡. 一种天然低分子量独活多糖及其制备方法和应用, ZL202010064940.2(授权2021-01-20，已转让)

[3] Yuan Q, Zhao L, Li H, Wei Z. Low-molecular-weight Tremella Aurantialba glucuronoxylomannan as well as preparation method and application thereof, US,11,434,306,B2(美国授权2022-09-06)

[4] Yuan Q, Zhao L, Li H, Wei Z. Low-molecular-weight Tremella Aurantialba glucuronoxylomannan as well as preparation method and application thereof, 2021103870(澳大利亚授权2021-07-05)

[5] 袁清霞, 赵龙岩, 马海琼, 唐浩, 谭鸿杰, 李婷婷, 魏时英, 黄金文, 姚玥, 胡亚平. 一种海蛇尾多糖硫酸酯衍生物的制备方法及应用, 中国, 202310117014.0

[6] 袁清霞, 赵龙岩, 吕坤凌, 黄金文, 李宏, 刘永宏, 高程海, 孙姝婧, 方梓毓. 一种非淀粉榄钱总多糖及其制备方法和作为肠道益生元的应用, 中国, 202210233639.9

[7] 赵龙岩, 袁清霞, 李婷婷, 马海琼, 李宏, 唐浩, 黄金文, 魏时英, 钟声平, 米顺利, 徐新亚,刘永宏, 高程海. 一种具有强效抗凝活性的海带多糖及其制备方法和应用, ZL202210411873.6(授权2023-05-12)

[8] 赵龙岩, 袁清霞, 吕坤凌, 刘永宏, 高程海, 李宏, 李婷婷, 马海琼, 唐浩, 黄金文, 魏时英. 一种蛋白核小球藻多糖混合物及其制备方法和作为新型益生元的应用, 202111390253.0

[9] 曾富华, 袁清霞等. 一种提高野生仙人掌多糖提取率的方法, ZL201210528643.4(授权2012-12-11)

[10] 曾富华, 袁清霞等. 一种野生仙人掌多糖PLGA微胶囊的制备方法, ZL201310033524.6(授权2013-01-29)